Simparica Trio Vs. NexGard Spectra

If you buy routine flea, tick, and heartworm treatments online, you may have spotted Simparica Trio and NexGard Spectra on the list of top dog parasite prevention treatments.

Since both of these products are highly popular, it may be challenging to figure out which one is the best for your furry friend. This blog compares Simparica Trio and NexGard Spectra in detail, making it easier for you to pick the appropriate one.

Simparica Trio Vs. Nexgard Spectra: Which One to Choose?

Simparica trio vs. Nexgard spectra

Manufactured by Zoetis, Simparica Trio is a monthly chewable tablet made with three proven ingredients, sarolaner, moxidectin, and pyrantel. This one tasty chew delivers the power of three powerful ingredients to keep your furry friend safe from internal and external parasites like fleas, ticks, and worms.

NexGard Spectra, on the other hand, is a Boehringer Ingelheim product that protects your dog against various parasites like fleas, ticks, mites, and worms. This all-in-one tasty chew is very easy to dose and is fully capable of keeping your dog safe from the threats these hitchhikers pose.

Key Features of Simparica Trio

  • Broad-spectrum, monthly chewable tablet
  • Flavorful tablet for easy administration
  • Kills fleas and prevents flea infestations
  • Kills 5 types of ticks including lone star ticks, Gulf Coast ticks, American dog ticks, black-legged ticks, and brown dog ticks
  • Treats and controls immature and adult roundworm and hookworms infections
  • Prevents the deadly heartworm disease caused by Dirofilaria immitis
  • Prevents Lyme disease in dogs by killing black-legged vector ticks

Key Features of NexGard Spectra

  • All-in-one, anti-parasitic chews for dogs
  • Highly-palatable beef flavored chewable
  • Rapidly kills fleas and ticks
  • Effective against American dog ticks, black-legged ticks, and Lone star ticks
  • Treats and controls gastrointestinal nematodes like roundworms, hookworms, and whipworms
  • Helps in the prevention of heartworm disease caused by Dirofilaria immitis
  • Helpful in the treatment of demodectic and sarcoptic mange
  • Helps prevent ear mites, eye worms, and lungworms
  • Helps in the treatment and prevention of flea tapeworms

Simparica Trio Vs. Nexgard Spectra: Comparison Chart

simparica trio vs nexgard spectra features comparison table chart

Also Read: Nexgard Vs. Comfortis for Dogs: Which Is the Better Product?

Main Difference between Simparica Trio & NexGard Spectra

Now that we have walked through the offerings of these products, it is clear that Simparica Trio and NexGard Spectra both cover a wide spectrum of parasites. However, the difference lies in their ingredients, composition, and coverage.

Simparica Trio comprises three active ingredients: sarolaner, moxidectin, and pyrantel. NexGard Spectra contains two key ingredients, afoxolaner and milbemycin oxime.

Simparica Trio begins killing fleas within 4 hours of administration and ticks within 8 hours of administration. Contrarily, its counterpart starts working on fleas and ticks within 8 hours.

NexGard Spectra offers extended protection against intestinal worms like whipworms and flea tapeworms. It also prevents ear mites, lungworms, and eyeworm infestations. Hence, NexGard Spectra comparatively covers more species of internal and external parasites as compared to Simparica Trio.

Final thoughts

NexGard Spectra and Simparica Trio are excellent options for dog parents looking for comprehensive protection against various parasites. NexGard Spectra is a monthly chewable that covers fleas, ticks, and mites and prevents heartworm disease. Additionally, it also protects your dog against intestinal worms as well as lungworm and eye worm infections. Simparica Trio, on the other hand, offers a triple-action formula that protects against fleas, ticks, roundworms, and hookworms and is also indicated for the prevention of heartworm disease with a once-a-month oral administration.

While both products are highly effective and recommended by veterinarians, it’s essential to consider your pet’s specific needs and health conditions. Ultimately, the choice between NexGard Spectra and Simparica Trio should be based on your veterinarian’s recommendation and what suits your dog’s individual needs best.


Is Simparica Trio better than NexGard Spectra?

NexGard Spectra and Simparica Trio are both globally recognized, vet-recommended all-in-one treatments for dogs. You can refer to the comparison table above to figure out which one is better for your dog’s individual needs or contact your veterinarian for the same.

Is NexGard Spectra safer than Simparica Trio?

NexGard Spectra and Simparica Trio have passed multiple laboratory experiments, field studies, and quality checks to meet the standards approved by FDA. In these studies, no adverse reactions have been reported when the products are used by following the guidelines provided by the manufacturers.

Can I use NexGard Spectra and Simparica Trio together?

Simparica Trio and NexGard Spectra should not be given together. They both offer efficient protection against fleas, ticks, and worms. Therefore, there is no point in giving them together. Plus, their ingredients may also cause adverse reactions.

Don’t miss out on more awesome product comparisons for your furry pals. Stay tuned to Budget Pet Care for the best tips and deals.