Advantage Multi vs. Frontline Plus vs. Revolution Plus: Ideal Parasite Protection for Cats

With the advancements in the pet healthcare industry, we are fortunate to get so many effective treatments for protecting our feline friends against various parasites. However, navigating this myriad of options and narrowing it down to one is a challenging feat.
Well, to dial down the confusion, we’ll discuss three of the most popular treatments for cats: Advantage Multi vs. Frontline Plus vs. Revolution Plus in this blog. Knowing their effectiveness, similarities, and differences, you’ll be able to make an informed decision. Also, make sure you check out the selection guide at the end; it’ll surely provide a great deal of clarity.
Explore the Fundamentals: Product Overview
In this segment, we’ll understand the fundamentals of these treatments. Knowing this will help you make an informed choice.
Advantage Multi (Advocate) for Cats

Advantage Multi is a broad-spectrum treatment for cats. This topical treatment contains Imidacloprid and Moxidectin as the active ingredients that kill fleas on contact, get rid of ear mites, and effectively prevent heartworm disease. It’s a monthly topical that also treats and controls common intestinal worms, including roundworms and hookworms.
Frontline Plus for Cats

Frontline Plus is a potent topical treatment for cats, widely popular for its reliable protection against fleas and ticks. The monthly treatment contains a powerful combination of Fipronil and S- Methoprene as the active ingredients. It kills all life stages of fleas and ticks andeliminates brown dog ticks, American dog ticks, lone star ticks, and deer ticks.Furthermore, it eliminates chewing lice and kills ticks that may transmit Lyme disease and other tick-borne diseases.
Revolution Plus for Cats

Revolution Plus is a quick-drying topical treatment designed to protect cats against a wide range of parasites. It leveragesSelamectin and Sarolaner to killfleas and treat and control ear mites. Plus, it treats and controls tick infestations by Gulf Coast ticks, lone star ticks, black-legged ticks, and American dog ticks. Moreover, it aids in the prevention of heartworm disease.The monthly treatment also treats and controls intestinal roundworms and hookworms.
Advantage Multi vs. Frontline Plus vs. Revolution Plus: Comparison Table
With the following table, you’ll figureout the similarities and differences between these treatments at a glance.

Which One is the Best for Your Cat?
Now that you know the fundamentals of these treatments, you can see all of them are capable and somewhat similar. So, how do you select one? We have prepared a selection guidecovering all the crucial aspects to keep in mind. Pay attention, as this will resolve all your queries:
- For protection against adult fleas, you can go with anyof them as all provide solid protection against adult fleas and flea infestations.
- When it comes to tick protection, Frontline Plus and Revolution Plus come close, with each protecting against 4 ticks. On the other hand, Advantage Multi sits out on this as it does not cover ticks.
- Both Advantage Multi for cats and Revolution Plus cover ear mites, which Frontline Plus does not.
- Frontline Plus aids in the prevention of Lyme disease by killing black-legged ticks.
- Advantage Multi and Revolution Plus aid in the prevention of heartworm disease, which Frontline Plus does not.
- Advantage Multi and Revolution Plus for cats protect against intestinal worms, including roundworms and hookworms, which Frontline Plus does not.
- Frontline Plus for cats is safe to use in breeding, pregnant, and lactating cats. However, the safe use of Advantage Multi and Revolution Plus in breeding, pregnant, and lactating catshas not been established.
- Both Frontline Plus and Revolution Plus are suitable for cats and kittens from 8 weeks of age and weighing at least 1.5 and 2.8 lbs, respectively. Advantage Multi, on the other hand, is recommended for cats and kittens from 9 weeks of age, weighing at least 2 lbs.
Keeping these points in mind, you can select the ideal treatment for your beloved feline friend. However, if you find considering so many peculiarities challenging, it’s best to consult your vet. They will resolve all your queries and suggest the treatment best suited for your cat.